Dr. Cornelia Weyand, MD

Targets of Immune Regeneration in Rheumatoid Arthritis

MAYO CLINIC PROCEEDINGS, 2014

Understanding immunosenescence to improve responses to vaccines

TURE IMMUNOLOGY, 2013

IL-7-and IL-15-Mediated TCR Sensitization Ebles T Cell Responses to Self-Antigens

JOURL OF IMMUNOLOGY, 2013

The janus head of T cell aging - autoimmunity and immunodeficiency.

Frontiers in immunology, 2013

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6

TURE MEDICINE, 2012

Sigling pathways in aged T cells - A reflection of T cell differentiation

SEMIRS IN IMMUNOLOGY, 2012

The Immunopathology of Giant Cell Arteritis: Diagnostic and Therapeutic Implications

JOURL OF NEURO-OPHTHALMOLOGY, 2012

CD8(+) CD45RA(+) CCR7(+) FOXP3(+) T Cells with Immunosuppressive Properties

JOURL OF IMMUNOLOGY, 2012

Chronic inflammation and aging: D damage tips the balance

CURRENT OPINION IN IMMUNOLOGY, 2012

Immune aging and autoimmunity

CELLULAR AND MOLECULAR LIFE SCIENCES, 2012

Sigl inhibition by the dual-specific phosphatase 4 impairs T cell

PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AM, 2012

Dampened ERK sigling in hematopoietic progenitor cells in rheumatoid arthritis

CLINICAL IMMUNOLOGY, 2012

Mechanisms of immunosenescence: lessons from models of accelerated immune aging

YEAR IN IMMUNOLOGY, 2012

Telomere dysfunction, autoimmunity and aging.

Aging and disease, 2011

Finding Balance: T cell Regulatory Receptor Expression during Aging.

Aging and disease, 2011

Magnetic Resonce Angiography in Extracranial Giant Cell Arteritis

JCR-JOURL OF CLINICAL RHEUMATOLOGY, 2011

Inflammation and cardiac outcome

CURRENT OPINION IN INFECTIOUS DISEASES, 2011

Regulation of T cell receptor sigling by activation-induced zinc influx

JOURL OF EXPERIMENTAL MEDICINE, 2011

Inflammation, Immunity, and Hypertension

HYPERTENSION, 2011

Haematopoietic stem and progenitor cells in rheumatoid arthritis

RHEUMATOLOGY, 2011

Blocking the NOTCH Pathway Inhibits Vascular Inflammation in Large-Vessel Vasculitis

CIRCULATION, 2011

Giant cell arteritis: immune and vascular aging as disease risk factors

ARTHRITIS RESEARCH & THERAPY, 2011

IFN-gamma and IL-17: the two faces of T-cell pathology in giant cell arteritis

CURRENT OPINION IN RHEUMATOLOGY, 2011

Inhibition and Genetic Ablation of the B7

CIRCULATION, 2010

Statins reduce endothelial cell apoptosis via inhibition of TRAIL expression on activated CD4 T

ATHEROSCLEROSIS, 2010

D-dependent protein kise catalytic subunit mediates T-cell loss in rheumatoid arthritis

EMBO MOLECULAR MEDICINE, 2010

Immune Aging and Rheumatoid Arthritis

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2010

Promoter choice and translatiol repression determine cell type-specific cell surface density of the

BLOOD, 2010

Insufficient Deactivation of the Protein Tyrosine Kise Lck Amplifies T

CIRCULATION RESEARCH, 2010

Th17 and Th1 T-Cell Responses in Giant Cell Arteritis

CIRCULATION, 2010

Telomeres and Immunological Diseases of Aging

GERONTOLOGY, 2010

Dendritic cells in atherosclerotic disease

CLINICAL IMMUNOLOGY, 2010

ERK-Dependent T Cell Receptor Threshold Calibration in Rheumatoid Arthritis

JOURL OF IMMUNOLOGY, 2009

Epigenetic regulation of killer immunoglobulin-like receptor expression in T cells

BLOOD, 2009

Rejuveting the immune system in rheumatoid arthritis

TURE REVIEWS RHEUMATOLOGY, 2009

Treating autoimmune disease by targeting CD8(+) T suppressor cells

EXPERT OPINION ON BIOLOGICAL THERAPY, 2009

Clinicopathologic Correlations in Giant Cell Arteritis A Retrospective Study of 107 Cases

OPHTHALMOLOGY, 2009

Deficiency of the D repair enzyme ATM in rheumatoid arthritis

JOURL OF EXPERIMENTAL MEDICINE, 2009

Telomerase insufficiency in rheumatoid arthritis

PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AM, 2009

Pathogenesis of medium- and large-vessel vasculitis

ZEITSCHRIFT FUR RHEUMATOLOGIE, 2009

Toll-Like Receptors 4 and 5 Induce Distinct Types of Vasculitis

CIRCULATION RESEARCH, 2009

Developments in the scientific understanding of rheumatoid arthritis

ARTHRITIS RESEARCH & THERAPY, 2009

Vascular damage in giant cell arteritis

AUTOIMMUNITY, 2009

Age-Dependent Sigture of Metallothionein Expression in Primary CD4 T Cell Responses Is Due to

REJUVETION RESEARCH, 2008

Inhibitory CD8(+) T cells in autoimmune disease

HUMAN IMMUNOLOGY, 2008

T-cell co-stimulatory pathways in autoimmunity

ARTHRITIS RESEARCH & THERAPY, 2008

T cells in arteritis and atherosclerosis

CURRENT OPINION IN LIPIDOLOGY, 2008

Vessel-specific Toll-like receptor profiles in human medium and large arteries

CIRCULATION, 2008

Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells

JOURL OF LEUKOCYTE BIOLOGY, 2008

The treatment of giant cell arteritis.

Reviews in neurological diseases, 2008

Defective proliferative capacity

ARTHRITIS AND RHEUMATISM, 2008

TLR-mediated induction of negative regulatory ligands on dendritic cells

JOURL OF MOLECULAR MEDICINE-JMM, 2008

T cell subset-specific susceptibility to aging

CLINICAL IMMUNOLOGY, 2008

Vessel wall-embedded dendritic cells induce T-Cell autoreactivity

CIRCULATION RESEARCH, 2008

Synoviocyte stimulation by the LFA-1-intercellular adhesion molecule-2-Ezrin-Akt pathway

JOURL OF IMMUNOLOGY, 2008

Synergistic proinflammatory effects of the antiviral cytokine interferon-alpha

CIRCULATION, 2007

Fractalkine mediates T cell-dependent proliferation of synovial fibroblasts in rheumatoid arthritis

ARTHRITIS AND RHEUMATISM, 2007

Unchecked CD70 expression on T cells lowers threshold for T cell activation in rheumatoid arthritis

JOURL OF IMMUNOLOGY, 2007

Immunopathologic aspects of rheumatoid arthritis

jourl of rheumatology. Supplement, 2007

The diagnosis of giant cell arteritis.

Reviews in neurological diseases, 2007

Aging and T-cell diversity

EXPERIMENTAL GERONTOLOGY, 2007

Infliximab for maintence of glucocorticosteroid-induced remission of giant cell arteritis - A r

ANLS OF INTERL MEDICINE, 2007

Functiol profile of activated dendritic cells in unstable atherosclerotic plaque

BASIC RESEARCH IN CARDIOLOGY, 2007

Occurrence of giant cell arteritis...suddenly.

Transactions of the American Ophthalmological Society, 2007

Immune-mediated mechanisms in atherosclerosis: Prevention and treatment of clinical manifestations

CURRENT PHARMACEUTICAL DESIGN, 2007

Pathogen-sensing plasmacytoid dendritic cells stimulate cytotoxic T

CIRCULATION, 2006

Siravastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo

ATHEROSCLEROSIS, 2006

Treatment of chronic inflammatory diseases with biologic agents

EXPERIMENTAL GERONTOLOGY, 2006

Immunosuppression in atherosclerosis mobilizing the opposition within

CIRCULATION, 2006

Treatment of giant cell arteritis using induction therapy with high-dose glucocorticoids

ARTHRITIS AND RHEUMATISM, 2006

Surgical pathology of noninfectious ascending aortitis

AMERICAN JOURL OF SURGICAL PATHOLOGY, 2006

Association of HLA-C3 and smoking with vasculitis in patients with rheumatoid arthritis

ARTHRITIS AND RHEUMATISM, 2006

Uncoupling of T-cell effector functions by inhibitory killer immunoglobulin-like receptors

BLOOD, 2006

T cell recognition and killing of vascular smooth muscle cells in acute corory syndrome

CIRCULATION RESEARCH, 2006

Pathomechanisms in rheumatoid arthritis - time for a string theory?

JOURL OF CLINICAL INVESTIGATION, 2006

T-cell-targeted therapies in rheumatoid arthritis

TURE CLINICAL PRACTICE RHEUMATOLOGY, 2006

Interleukin 12 induces T-cell recruitment into the atherosclerotic plaque

CIRCULATION RESEARCH, 2006

Telomeres, immune aging and autoimmunity

EXPERIMENTAL GERONTOLOGY, 2006

Lymphoma in rheumatoid arthritis: An immune system set up for failure

ARTHRITIS AND RHEUMATISM, 2006

TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic

JOURL OF EXPERIMENTAL MEDICINE, 2006

Tissue trafficking patterns of effector memory CD4+T cells in rheumatoid arthritis

ARTHRITIS AND RHEUMATISM, 2005

Fractalkine receptor polymorphisms V249I and T280M as genetic risk factors for restenosis

THROMBOSIS AND HAEMOSTASIS, 2005

BLyS and APRIL in rheumatoid arthritis

JOURL OF CLINICAL INVESTIGATION, 2005

T cell development and receptor diversity during aging

CURRENT OPINION IN IMMUNOLOGY, 2005

Modulation of CD28 expression with anti-tumor necrosis factor alpha therapy in rheumatoid arthritis

ARTHRITIS AND RHEUMATISM, 2005

Lipopolysaccharide, CD14 and Toll-like receptors

Future cardiology, 2005

Distinct transcriptiol control mechanisms of killer immunoglobulin-like receptors in tural killer

JOURL OF BIOLOGICAL CHEMISTRY, 2005

B cells as a therapeutic target in autoimmune diseases

EXPERT OPINION ON THERAPEUTIC TARGETS, 2005

B cells in rheumatoid synovitis

ARTHRITIS RESEARCH & THERAPY, 2005

The influence of age on T cell generation and TCR diversity

JOURL OF IMMUNOLOGY, 2005

Cell-based immunotherapy with suppressor CD8(+) T cells in rheumatoid arthritis

JOURL OF IMMUNOLOGY, 2005

Opposite effects of CX3CRI receptor polymorphisms V2491

THROMBOSIS AND HAEMOSTASIS, 2005

T cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis

ARTHRITIS AND RHEUMATISM, 2005

Toll-like receptors in giant cell arteritis

CLINICAL IMMUNOLOGY, 2005

Rheumatoid arthritis

IMMUNOLOGICAL REVIEWS, 2005

Vascular dendritic cells in giant cell arteritis

HUMAN IMMUNOLOGY: PATIENT-BASED RESEARCH, 2005

Costimulatory pathways in rheumatoid synovitis and T-cell senescence

HUMAN IMMUNOLOGY: PATIENT-BASED RESEARCH, 2005

Increased CD4+ T cell infiltrates in rheumatoid arthritis

ARTHRITIS AND RHEUMATISM, 2005

The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis

ARTHRITIS RESEARCH & THERAPY, 2005

Rheumatoid arthritis is an independent risk factor for multi-vessel corory artery disease

ARTHRITIS RESEARCH & THERAPY, 2005

Thrombospondin 2 functions as an endogenous regulator of angiogenesis

AMERICAN JOURL OF PATHOLOGY, 2004

Genetics of rheumatoid arthritis: Is there a pattern predicting extraarticular manifestations?

ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2004

Stimulatory killer Ig-like receptors modulate T cell activation through DAP12-dependent

JOURL OF IMMUNOLOGY, 2004

VEGF gene polymorphisms and susceptibility to rheumatoid arthritis

RHEUMATOLOGY, 2004

Stem cell aging and autoimmunity in rheumatoid arthritis

TRENDS IN MOLECULAR MEDICINE, 2004

Tumor necrosis factor-alpha

JOURL OF BIOLOGICAL CHEMISTRY, 2004

Lymphotoxin beta-mediated stimulation of synoviocytes in rheumatoid arthritis

ARTHRITIS AND RHEUMATISM, 2004

T-cell regulation in rheumatoid arthritis

CURRENT OPINION IN RHEUMATOLOGY, 2004

How aggressive should initial therapy for rheumatoid arthritis be? Factors

RHEUMATOLOGY, 2004

T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent

TRENDS IN MOLECULAR MEDICINE, 2004

Biology of T lymphocytes

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2004

Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis

JOURL OF EXPERIMENTAL MEDICINE, 2004

HLA-DRB1 haplotype did not affect the medium

Modern rheumatology, 2004

The double life of NK receptors: stimulation or co-stimulation?

TRENDS IN IMMUNOLOGY, 2004

Immunopathways in giant cell arteritis and polymyalgia rheumatica

AUTOIMMUNITY REVIEWS, 2004

Prognostic markers of radiographic progression in early rheumatoid arthritis

ARTHRITIS AND RHEUMATISM, 2004

Premature telomeric loss in rheumatoid arthritis is genetically determined

PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AM, 2003

Giant-cell arteritis and polymyalgia rheumatica

ANLS OF INTERL MEDICINE, 2003

Synoviocyte-mediated expansion of inflammatory T cells in rheumatoid synovitis is dependent on CD47

JOURL OF IMMUNOLOGY, 2003

Homeostatic control of T-cell generation in neotes

BLOOD, 2003

Immunosenescence, autoimmunity, and rheumatoid arthritis

EXPERIMENTAL GERONTOLOGY, 2003

De novo expression of killer immunoglobulin-like receptors

CIRCULATION RESEARCH, 2003

Medium- and large-vessel vasculitis.

New England jourl of medicine, 2003

The power of the third dimension: tissue architecture and autoimmunity in rheumatoid arthritis

CURRENT OPINION IN RHEUMATOLOGY, 2003

CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation

BLOOD, 2003

Selective activation of the c-Jun NH2

JOURL OF EXPERIMENTAL MEDICINE, 2003

B cells as a therapeutic target in autoimmune disease

ARTHRITIS RESEARCH & THERAPY, 2003

Aging, autoimmunity and arthritis

Arthritis research & therapy, 2003

Ectopic germil center formation in rheumatoid synovitis

IMMUNE MECHANISMS AND DISEASE, 2003

Molecular basis for the loss of CD28 expression in senescent T cells

JOURL OF BIOLOGICAL CHEMISTRY, 2002

Trapping of misdirected dendritic cells in the granulomatous lesions of giant cell arteritis

AMERICAN JOURL OF PATHOLOGY, 2002

Reactive nitrogen intermediates in giant cell arteritis - Selective nitration of neocapillaries

AMERICAN JOURL OF PATHOLOGY, 2002

Premature immunosenescence in rheumatoid arthritis.

jourl of rheumatology, 2002

CD8 T cells are required for the formation of ectopic germil centers in rheumatoid synovitis

JOURL OF EXPERIMENTAL MEDICINE, 2002

Human leukocyte antigen class II immune response genes, female gender

JOURL OF VASCULAR SURGERY, 2002

Formation of the killer Ig-like receptor repertoire on CD4(+)CD28(null) T cells

JOURL OF IMMUNOLOGY, 2002

T-cell-mediated lysis of endothelial cells in acute corory syndromes

CIRCULATION, 2002

Therapeutic effects of acetylsalicylic acid in giant cell arteritis

ARTHRITIS AND RHEUMATISM, 2002

Bi-directiol modulation of T cell-dependent antibody production by prostaglandin E-2

INTERTIOL IMMUNOLOGY, 2002

Pathogenic mechanisms in giant cell arteritis.

Cleveland Clinic jourl of medicine, 2002

Cytokines in giant-cell arteritis.

Cleveland Clinic jourl of medicine, 2002

Value of immunological markers in predicting responsiveness to influenza vaccition in elderly

JOURL OF VIROLOGY, 2001

T cell activation in rheumatoid synovium is B cell dependent

JOURL OF IMMUNOLOGY, 2001

T-cell immunity in acute corory syndromes

MAYO CLINIC PROCEEDINGS, 2001

Down-regulation of CD28 expression by TNF-alpha

JOURL OF IMMUNOLOGY, 2001

Ectopic lymphoid organogenesis - A fast track for autoimmunity

AMERICAN JOURL OF PATHOLOGY, 2001

Lymphoid neogenesis in rheumatoid synovitis

JOURL OF IMMUNOLOGY, 2001

Genetic similarity in inflammatory and degenerative abdomil aortic aneurysms

Rasmussen, T. E., Hallett, J. W., Schulte, S., Harmsen, W. S., O'Fallo, 2001

Major histocompatibility complex class I

JOURL OF EXPERIMENTAL MEDICINE, 2001

Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis

TRENDS IN IMMUNOLOGY, 2001

Molecular fingerprint of interferon-gamma sigling in unstable angi

CIRCULATION, 2001

Functiol disruption of the CD28 gene transcriptiol initiator in senescent T cells

JOURL OF BIOLOGICAL CHEMISTRY, 2001

T cell homeostasis and autoreactivity in rheumatoid arthritis.

Current directions in autoimmunity, 2001

Lymphoid microstructures in rhe