
Affiliated with a Castle Connolly Top Hospital
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Alameda Alliance
All Other Third Party
Crown Cork and Seal Company
FirstMerit Corporation
HealthComp
Medicare
San Francisco Health Plan
State of California
State of Tennessee
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275 W MacArthur Blvd
Oakland, CA 94611
(510) 752-1000
Landscape and variation of R secondary structure across the human transcriptome.
ture, 2014
Long Noncoding Rs: Cellular Address Codes in Development and Disease
CELL, 2013
Control of somatic tissue differentiation by the long non-coding R TINCR
TURE, 2013
A mammalian pseudogene lncR at the interface of inflammation and anti-inflammatory therapeutics.
eLife, 2013
Transposition of tive chromatin for fast and sensitive epigenomic profiling of open chromatin
ture methods, 2013
Aging, Rejuvetion, and Epigenetic Reprogramming: Resetting the Aging Clock
CELL, 2012
A long noncoding R maintains active chromatin to coordite homeotic gene expression
TURE, 2011
Genome-wide mapping of R structure using nuclease digestion and high-throughput sequencing.
ture protocols, 2013
Cytotopic localization by long noncoding Rs
CURRENT OPINION IN CELL BIOLOGY, 2013
The NeST Long ncR Controls Microbial Susceptibility
CELL, 2013
Rejuvetion of Gene Expression Pattern of Aged Human Skin by Broadband Light Treatment
JOURL OF INVESTIGATIVE DERMATOLOGY, 2013
SeqFold: Genome-scale reconstruction of R secondary structure
GENOME RESEARCH, 2013
R SHAPE alysis in living cells
TURE CHEMICAL BIOLOGY, 2013
Systematic reconstruction of R functiol motifs with high-throughput microfluidics
TURE METHODS, 2012
Identification of proteins binding coding and non-coding human Rs using protein microarrays
BMC GENOMICS, 2012
Genome-wide Measurement of R Folding Energies
MOLECULAR CELL, 2012
Detection of Long Non-Coding R in Archival Tissue
PLOS ONE, 2012
A Molecular Sigture for Purified Definitive Endoderm Guides Differentiation
STEM CELLS AND DEVELOPMENT, 2012
Active chromatin and noncoding Rs: an intimate relationship
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2012
Suppression of progenitor differentiation requires the long noncoding R ANCR
GENES & DEVELOPMENT, 2012
Transcriptiol profiling of long non-coding Rs
GENOME BIOLOGY, 2012
Genome Regulation by Long Noncoding Rs
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81, 2012
Chromatin isolation by R purification (ChIRP).
Jourl of visualized experiments : JoVE
Genomic Maps of Long Noncoding R Occupancy Reveal Principles of R-Chromatin Interactions
MOLECULAR CELL, 2011
Direct Lineage Conversion of Termilly Differentiated Hepatocytes to Functiol Neurons
CELL STEM CELL, 2011
Molecular Mechanisms of Long Noncoding Rs
MOLECULAR CELL, 2011
Disruption of PPAR gamma
JOURL OF CLINICAL INVESTIGATION, 2011
Understanding the transcriptome through R structure
TURE REVIEWS GENETICS, 2011
Crystal structure of the N-termil region of human Ash2L shows a winged
EMBO REPORTS, 2011
Extensive and coordited transcription of noncoding Rs within cell-cycle promoters
TURE GENETICS, 2011
Long noncoding Rs and human disease
TRENDS IN CELL BIOLOGY, 2011
Dymic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptiol Networks
PLOS GENETICS, 2011
R templating the epigenome Long noncoding Rs as molecular scaffolds
EPIGENETICS, 2011
Long Intergenic Noncoding Rs: New Links in Cancer Progression
CANCER RESEARCH, 2011
Noncoding R Landmarks of Pluripotency and Reprogramming
CELL STEM CELL, 2010
G1 arrest and differentiation can occur independently of Rb family function
JOURL OF CELL BIOLOGY, 2010
Genome-wide measurement of R secondary structure in yeast
TURE, 2010
Long noncoding R in genome regulation Prospects and mechanisms
R BIOLOGY, 2010
HOTAIR Flight of noncoding Rs in cancer metastasis
CELL CYCLE, 2010
Long Noncoding R as Modular Scaffold of Histone Modification Complexes
SCIENCE, 2010
Long non-coding R HOTAIR reprograms chromatin state to promote cancer metastasis
TURE, 2010
A TGF beta-Responsive Gene Sigture Is Associated with a Subset of Diffuse Scleroderma with
JOURL OF INVESTIGATIVE DERMATOLOGY, 2010
The histone demethylase UTX ebles RB-dependent cell fate control
GENES & DEVELOPMENT, 2010
Atomic Demarcation of Cells: Genes to Patterns
SCIENCE, 2009
Identification, molecular characterization
PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AM, 2009
Gene dates, parties and galas Symposium on Chromatin Dymics and Higher Order Organization
EMBO REPORTS, 2009
Hierarchical Maintence of MLL Myeloid Leukemia Stem Cells Employs a Transcriptiol Program Shared
CELL STEM CELL, 2009
Combining biological gene expression sigtures in predicting outcome in breast cancer
EUROPEAN JOURL OF CANCER, 2008
Deletiol tolerance mediated by extrathymic Aire-expressing cells
SCIENCE, 2008
Mechanisms of an autoimmunity syndrome in mice caused by a domint mutation in Aire
JOURL OF CLINICAL INVESTIGATION, 2008
A systems biology approach to atomic diversity of skin
JOURL OF INVESTIGATIVE DERMATOLOGY, 2008
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
TURE, 2008
Systematic functiol characterization of cis-regulatory motifs in human core promoters
GENOME RESEARCH, 2008
A dermal HOX transcriptiol program regulates site-specific epidermal fate
GENES & DEVELOPMENT, 2008
CSN5 isopeptidase activity links COP9 siglosome activation to breast cancer progression
CANCER RESEARCH, 2008
A histone H3 lysine 27 demethylase regulates animal posterior development
TURE, 2007
Turning skin into embryonic stem cells
TURE MEDICINE, 2007
Functiol demarcation of active and silent chromatin domains in human HOX loci by Noncoding Rs
CELL, 2007
Decoding global gene expression programs in liver cancer by noninvasive imaging
TURE BIOTECHNOLOGY, 2007
A transcriptiol program mediating entry into cellular quiescence
PLOS GENETICS, 2007
Genome-wide alysis of KAP1 binding suggests autoregulation of KRAB-ZNFs
PLOS GENETICS, 2007
Patterning skin pigmentation via dickkopf
JOURL OF INVESTIGATIVE DERMATOLOGY, 2007
Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
JOURL OF EXPERIMENTAL MEDICINE, 2006
Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer
PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AM, 2006
Atomic demarcation by positiol variation in fibroblast gene expression programs
PLOS GENETICS, 2006
MYC can induce D breaks in vivo and in vitro independent of reactive oxygen species
CANCER RESEARCH, 2006
From description to causality - Mechanisms of gene expression sigtures in cancer
CELL CYCLE, 2006
Genetic regulators of large-scale transcriptiol sigtures in cancer
TURE GENETICS, 2006
Microarray alysis of stem cells and differentiation
STEM CELL TOOLS AND OTHER EXPERIMENTAL PROTOCOLS, 2006
Learning more from microarrays: Insights from modules and networks
JOURL OF INVESTIGATIVE DERMATOLOGY, 2005
Robustness, scalability
PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AM, 2005
Gene expression sigture of fibroblast serum response predicts human cancer progression
PLoS biology, 2004
Endothelial cell diversity revealed by global expression profiling
PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AM, 2003
Myelogenous leukemia cutis resembling stasis dermatitis
JOURL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2003
Genomewide view of gene silencing by small interfering Rs
PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AM, 2003
Diversity, topographic differentiation, and positiol memory in human fibroblasts
PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AM, 2002
Dissecting Fas sigling with an altered-specificity death-domain mutant
PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AM, 1999
Activation of apoptosis sigl regulating kise 1 (ASK1) by the adapter protein Daxx
SCIENCE, 1998
ASYMMETRIC RETRACTION OF GROWTH CONE FILOPODIA FOLLOWING FOCAL ICTIVATION OF CALCINEURIN
TURE, 1995
CYCLOSPORINE-MEDIATED INHIBITION OF BOVINE CALCINEURIN BY CYCLOPHILIN-A AND CYCLOPHILIN-B
PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AM, 1992
Landscape and variation of RNA secondary structure across the human transcriptome.
Nature, 2014
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
CELL, 2013
Long Noncoding RNAs: Cellular Address Codes in Development and Disease
CELL, 2013
Control of somatic tissue differentiation by the long non-coding RNA TINCR
NATURE, 2013
A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics.
eLife, 2013
Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin
Nature methods, 2013
Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock
CELL, 2012
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
NATURE, 2011
Targeted disruption of hotair leads to homeotic transformation and gene derepression.
Cell reports, 2013
Genome-wide mapping of RNA structure using nuclease digestion and high-throughput sequencing.
Nature protocols, 2013
Cytotopic localization by long noncoding RNAs
CURRENT OPINION IN CELL BIOLOGY, 2013
The NeST Long ncRNA Controls Microbial Susceptibility
CELL, 2013
Rejuvenation of Gene Expression Pattern of Aged Human Skin by Broadband Light Treatment
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2013
SeqFold: Genome-scale reconstruction of RNA secondary structure integrating high-throughput
GENOME RESEARCH, 2013
RNA SHAPE analysis in living cells
NATURE CHEMICAL BIOLOGY, 2013
Systematic reconstruction of RNA functional motifs with high-throughput microfluidics
NATURE METHODS, 2012
Identification of proteins binding coding and non-coding human RNAs using protein microarrays
BMC GENOMICS, 2012
Genome-wide Measurement of RNA Folding Energies
MOLECULAR CELL, 2012
Detection of Long Non-Coding RNA in Archival Tissue
PLOS ONE, 2012
Transcriptome sequencing in Sezary syndrome identifies Sezary cell
BLOOD, 2012
A Molecular Signature for Purified Definitive Endoderm Guides Differentiation
STEM CELLS AND DEVELOPMENT, 2012
The Transcription Factor ZNF217 Is a Prognostic Biomarker
CANCER DISCOVERY, 2012
Active chromatin and noncoding RNAs: an intimate relationship
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2012
Suppression of progenitor differentiation requires the long noncoding RNA ANCR
GENES & DEVELOPMENT, 2012
Transcriptional profiling of long non-coding RNAs
GENOME BIOLOGY, 2012
Genome Regulation by Long Noncoding RNAs
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81, 2012
Chromatin isolation by RNA purification (ChIRP).
Journal of visualized experiments : JoVE
High throughput automated chromatin immunoprecipitation as a platform for drug screening
LAB ON A CHIP, 2012
Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions
MOLECULAR CELL, 2011
Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons
CELL STEM CELL, 2011
Molecular Mechanisms of Long Noncoding RNAs
MOLECULAR CELL, 2011
Disruption of PPAR gamma
JOURNAL OF CLINICAL INVESTIGATION, 2011
Understanding the transcriptome through RNA structure
NATURE REVIEWS GENETICS, 2011
Crystal structure of the N-terminal region of human Ash2L shows a winged
EMBO REPORTS, 2011
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
NATURE GENETICS, 2011
Long noncoding RNAs and human disease
TRENDS IN CELL BIOLOGY, 2011
Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks
PLOS GENETICS, 2011
RNA templating the epigenome Long noncoding RNAs as molecular scaffolds
EPIGENETICS, 2011
Long Intergenic Noncoding RNAs: New Links in Cancer Progression
CANCER RESEARCH, 2011
Noncoding RNA Landmarks of Pluripotency and Reprogramming
CELL STEM CELL, 2010
G1 arrest and differentiation can occur independently of Rb family function
JOURNAL OF CELL BIOLOGY, 2010
Genome-wide measurement of RNA secondary structure in yeast
NATURE, 2010
Long noncoding RNA in genome regulation Prospects and mechanisms
RNA BIOLOGY, 2010
HOTAIR Flight of noncoding RNAs in cancer metastasis
CELL CYCLE, 2010
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
SCIENCE, 2010
Tumor suppression by the histone demethylase UTX
CELL CYCLE, 2010
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
NATURE, 2010
A TGF beta-Responsive Gene Signature Is Associated with a Subset of Diffuse Scleroderma with
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010
The histone demethylase UTX enables RB-dependent cell fate control
GENES & DEVELOPMENT, 2010
Anatomic Demarcation of Cells: Genes to Patterns
SCIENCE, 2009
Identification, molecular characterization
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES O, 2009
Gene dates, parties and galas Symposium on Chromatin Dynamics and Higher Order Organization
EMBO REPORTS, 2009
Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis
CANCER CELL, 2009
Modeling Inducible Human Tissue Neopl
CANCER CELL, 2009
Regeneration, repair and remembering identity: the three Rs of Hox gene expression
TRENDS IN CELL BIOLOGY, 2009
Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program
CELL STEM CELL, 2009
Molecular Framework for Response to Imatinib Mesylate in Systemic Sclerosis
ARTHRITIS AND RHEUMATISM, 2009
ING4 Mediates Crosstalk between Histone H3 K4 Trimethylation
MOLECULAR CELL, 2009
SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-kappa B-Dependent Gene Expression
CELL, 2009
Genome-Wide Views of Chromatin Structure
ANNUAL REVIEW OF BIOCHEMISTRY, 2009
Global Expression Profiling in Atopic Eczema Reveals Reciprocal Expression of Inflammatory
PLOS ONE, 2008
Stemness, cancer and cancer stem cells
CELL CYCLE, 2008
Combining biological gene expression signatures in predicting outcome in breast cancer
EUROPEAN JOURNAL OF CANCER, 2008
Deletional tolerance mediated by extrathymic Aire-expressing cells
SCIENCE, 2008
Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3
GENES & DEVELOPMENT, 2008
Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire
JOURNAL OF CLINICAL INVESTIGATION, 2008
Module map of stem cell genes guides creation of epithelial cancer stem cells
CELL STEM CELL, 2008
A systems biology approach to anatomic diversity of skin
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2008
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
NATURE, 2008
Reversal of aging by NF kappa B blockade
CELL CYCLE, 2008
Systematic functional characterization of cis-regulatory motifs in human core promoters
GENOME RESEARCH, 2008
A dermal HOX transcriptional program regulates site-specific epidermal fate
GENES & DEVELOPMENT, 2008
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression
CANCER RESEARCH, 2008
Revealing targeted therapy for human cancer by gene module maps
CANCER RESEARCH, 2008
Motif module map reveals enforcement of aging by continual NF-kappa B activity
GENES & DEVELOPMENT, 2007
A histone H3 lysine 27 demethylase regulates animal posterior development
NATURE, 2007
Turning skin into embryonic stem cells
NATURE MEDICINE, 2007
Functional demarcation of active and silent chromatin domains in human HOX loci by Noncoding RNAs
CELL, 2007
Decoding global gene expression programs in liver cancer by noninvasive imaging
NATURE BIOTECHNOLOGY, 2007
A transcriptional program mediating entry into cellular quiescence
PLOS GENETICS, 2007
Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs
PLOS GENETICS, 2007
Patterning skin pigmentation via dickkopf
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007
GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN
ONCOGENE, 2007
Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
JOURNAL OF EXPERIMENTAL MEDICINE, 2006
Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES O, 2006
Anatomic demarcation by positional variation in fibroblast gene expression programs
PLOS GENETICS, 2006
MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species
CANCER RESEARCH, 2006
From description to causality - Mechanisms of gene expression signatures in cancer
CELL CYCLE, 2006
Genetic regulators of large-scale transcriptional signatures in cancer
NATURE GENETICS, 2006
Microarray analysis of stem cells and differentiation
STEM CELL TOOLS AND OTHER EXPERIMENTAL PROTOCOLS, 2006
Predicting a local recurrence after breast-conserving therapy by gene expression profiling
BREAST CANCER RESEARCH, 2006
Learning more from microarrays: Insights from modules and networks
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2005
Robustness, scalability
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES O, 2005
Gene expression signature of fibroblast serum response predicts human cancer progression
PLoS biology, 2004
Kinetics and specificity of Fas ligand induction in toxic epidermal necrolysis
ARCHIVES OF DERMATOLOGY, 2004
Endothelial cell diversity revealed by global expression profiling
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES O, 2003
Eruptive xanthomas associated with olanzapine use
ARCHIVES OF DERMATOLOGY, 2003
Myelogenous leukemia cutis resembling stasis dermatitis
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2003
Genomewide view of gene silencing by small interfering RNAs
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES O, 2003
Diversity, topographic differentiation, and positional memory in human fibroblasts
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES O, 2002
Proteases for cell suicide: Functions and regulation of caspases
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2000
Dissecting Fas signaling with an altered-specificity death-domain mutant
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES O, 1999
Activation of apoptosis signal regulating kinase 1 (ASK1) by the adapter protein Daxx
SCIENCE, 1998
Essential role of CED-4 oligomerization in CED-3 activation and apoptosis
SCIENCE, 1998
Autoproteolytic activation of pro-caspases by oligomerization
MOLECULAR CELL, 1998
Daxx, a novel Fas-binding protein that activates JNK and apoptosis
CELL, 1997
ASYMMETRIC RETRACTION OF GROWTH CONE FILOPODIA FOLLOWING FOCAL INACTIVATION OF CALCINEURIN
NATURE, 1995
ACTIVATION OF CLN1 AND CLN2 G(1) CYCLIN GENE-EXPRESSION BY BCK2
MOLECULAR AND CELLULAR BIOLOGY, 1995
ACTIVE-SITE MUTANTS OF HUMAN CYCLOPHILIN
PROTEIN SCIENCE, 1992
CYCLOSPORINE-MEDIATED INHIBITION OF BOVINE CALCINEURIN BY CYCLOPHILIN-A AND CYCLOPHILIN-B
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES O, 1992
A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults and the elderly. Internists are trained in the diagnosis and treatment of cancer, infections and diseases affecting the heart, blood, kidneys, joints and digestive, respiratory and vascular systems. They are also trained in the essentials of primary care internal medicine, which incorporates an understanding of disease prevention, wellness, substance abuse, mental health and effective treatment of common problems of the eyes, ears, skin, nervous system and reproductive organs.
Contact Dr. Chang to book an appointment today.