Dr. Danielle DePeralta, MD

Dr. Danielle DePeralta, MD

Accepting patients


    Danielle DePeralta, MD, FACS is double board-certified in surgery and surgical oncology, with dual fellowship training in complex surgical oncology and hepato-pancreato-biliary surgery. She specializes in surgical treatment of diseases of the liver, pancreas, and gastrointestinal tract. Named a Castle Connolly Top Doctor in 2021 and 2022, Dr. DePeralta is a leader in her field and is an active member of the Society of Surgical Oncology, American College of Surgeons and International Hepatopancreatobiliary Association. She is the Northwell Physician Champion for the Canopy Cancer Collective, a multi-center team that focuses on improving care for patients with pancreatic cancer. She is also heavily involved in clinical trials and innovations related to cancer care, including regional therapies that target cancer that has spread but is still localized to the liver or peritoneal cavity. She was instrumental in bringing pressurized intraperitoneal aerosolized chemotherapy (PIPAC)-a treatment that can help those with few options-to New York. Long Island Jewish Medical Center is now one of only three sites in the nation to offer such therapy.Treating some of the most aggressive cancers, Dr. DePeralta knows she's seeing patients at their most vulnerable moments. While focusing on giving them their lives back, she often forms close relationships with her patients. "I try to treat all of my patients the way that I hope someone would care for my mother, my husband, my son," she says.Connecting with patients meaningfully is important to Dr. DePeralta, who has a special interest in the human side of medicine. She studied philosophy in college alongside molecular biology and biochemistry. She also completed a medical ethics fellowship during her surgical residency training at Massachusetts General Hospital/Harvard Medical School. Her training has taken her around the world to Uganda, Panama and India, which has fueled her interest in global health and quality health care for all.Her compassion is also shared by her team, from the care navigators and office staff to the nurses and residents. "We're very lucky to be so well-supported with a great team that cares a lot about our patients," Dr. DePeralta says.Having a team like this serves to strengthen the bonds with her patients, who she learns from each day. "They teach me that you have to keep trying-keep pushing and it's my job to keep supporting them.It's extremely rewarding to treat someone who was very sick, who you see a year down the road is cancer-free and living a normal life."

    Castle Connolly Top Doctor

    Castle Connolly Top Doctors are doctor-nominated and selected by a physician-led research team.

    Medical Specialties and Areas of Expertise


    Education & Training

    Massachusetts General Hospital (Residency)

    Indiana University Hospitals School of Medicine (Fellowship)

    H Lee Moffitt Cancer Center & Research Inst (Fellowship)

    Medical Degree - Tufts University School of Medicine

    Medical Conditions Treated

    conditions treated by a Surgeon, like Dr. Danielle DePeralta, may include:

    Please contact Dr. DePeralta's office for more information or to schedule a consultation.

    Medical Procedures Performed

    procedures performed by a Surgeon, like Dr. Danielle DePeralta, may include:

    Surgical Consultation, Surgery, Neurosurgery Consultation, Pre-Surgery Consultation, Surgery Consultation, Pediatric Pre-Surgery Consultation, Pre-Surgery Consultation, Laparoscopic Surgery Consultation, Gallbladder Removal / Cholecystectomy, Appendicitis / Appendectomy, Eyelid Surgery / Blepharoplasty, Brain Tumor Evaluation, Brain Aneurysm Treatment, Stroke Treatment (Acute), Refractive Lens Exchange, Brain Surgery, Skull Base Surgery, Surgery Follow Up, Neurosurgery Follow Up, Pre-Surgery Follow Up, Surgical Follow Up, Pediatric Pre-Surgery Follow Up, Laparoscopic Surgery Follow Up, Neuro-Oncology Consultation, Surgery Second Opinion, Wrist Arthroscopy, Endoscopic Eyebrow Elevation, Forehead Correction, Hand & Microsurgery Specialist Consultation, Hand & Microsurgery Specialist Follow Up, Head & Neck Surgery, Pelvic Surgery, Ptosis Repair, Central Line Placement, Gender Confirmation Surgery, Cerebral Shunt, Surgical Infections, Tube Thoracotomy, Laparoscopic Colectomy, Amputation, Limb Surgery, Minimally Invasive Surgery, Mastectomy, Upper Extremity Tendon Repair, Toe-to-Thumb Transplant, Upper Extremity Nerve Repair, Upper Extremity Joint Replacement, Upper Extremity Amputation, Reflux Surgery, Spleen Surgery, Implantable Contact Lens (ICL) Surgery, YAG Laser Procedure, Colon Surgery, Distal Pancreatectomy, Splenectomy, Sleeve Gastrectomy, Orthopedic Follow Up (Hand), Orthopedic Consultation (Hand), Cranial Bypass, Esophagogastroduodenoscopy (EGD), Esophageal Surgery, Gastrectomy, Laparoscopy, Lymph Node Biopsy, Pancreatic Surgery, Paraesophageal Surgery, Parathyroid Surgery, Head and Neck Cancer Screening, Whipple Procedure, Hepatic Surgery, Complex Gastrointestinal Surgery, Laparoscopy Consultation, Minimally Invasive Surgery Consultation, Magnetic Sphincter Augmentation (MSA), Abdominal Wall Reconstruction, Gastric Bypass Surgery, Pyloromyotomy, Percutaneous Endoscopic Gastrostomy (PEG) and Small Bowel Resection

    For detailed information, please contact Dr. DePeralta's office.


    Please contact Dr. DePeralta's office to confirm accepted insurance plans.


    Northwell Health

    450 Lakeville Road

    New Hyde Park, NY 11042

    (516) 487-9454

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    Frequently Asked Questions

    Is Dr. Danielle DePeralta accepting new patients?

    Yes, Dr. Danielle DePeralta is accepting new patients at this time.

    Does Dr. Danielle DePeralta offer online booking?

    Please contact Dr. DePeralta's office at (516) 487-9454 for information about online booking, telehealth, or to schedule an appointment.

    Does Dr. Danielle DePeralta offer telehealth appointments?

    Please contact Dr. DePeralta's office at (516) 487-9454 for information telehealth appointment availability or for scheduling assistance.

    Which language(s) does Dr. Danielle DePeralta speak?

    Dr. Danielle DePeralta speaks English.

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